Formulation and evaluation of quince seeds mucilage – sodium alginate microspheres for sustained delivery of cefixime and its toxicological studies

Quince seed mucilage was used in a combination of sodium alginate to develop sustained-release microspheres cefixime. Physical characterizations such as FTIR, TGA, DSC, and SEM were performed on the prepared microspheres. The swelling maximum at pH 7.4 reduced acidic pH. average particle size ranged from 679 µm ± 0.21 810 0.31, while drug encapsulation efficiency range found 73.76 0.24–85.63 0.46. In vitro release profile QSM-alginate-cefixime followed Korsmeyer-Peppas model (R2 = 0.9732-–0.9946); non-Fickian we value n > 1. This study reveals benefits QSM-alginate for sustained cefixime without any toxicity it also improved antibacterial properties.